Cloned (Comment) | Organism |
---|---|
when expressed in multicopy, the human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40998 | - |
x * 40998, calculated from sequence | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 3-demethylubiquinol-10 | Homo sapiens | the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-10, 1. the methylation of 3,4-dihydroxy-5-all-trans-decaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-10 | S-adenosyl-L-homocysteine + ubiquinol-10 + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NZJ6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | wide substrate specificity. The enzyme methylates both eukaryotic substrates 3,4-dihydroxy-5-farnesylbenzoic acid (this activity is classified as EC 2.1.1.114) and demethylubiquinol-3 and the distinct prokaryotic substrate 3-((2E,6E)-farnesyl)benzene-1,2-diol | Homo sapiens | ? | - |
? | |
S-adenosyl-L-methionine + 3-demethylubiquinol-10 | the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-10, 1. the methylation of 3,4-dihydroxy-5-all-trans-decaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-10 | Homo sapiens | S-adenosyl-L-homocysteine + ubiquinol-10 + H+ | - |
? | |
S-adenosyl-L-methionine + 3-demethylubiquinol-3 | i.e. 5-(2E,6E)-farnesyl-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone, in vitro assay | Homo sapiens | S-adenosyl-L-homocysteine + ubiquinol-3 | - |
? | |
S-adenosyl-L-methionine + 3-demethylubiquinol-6 | 3-demethylubiquinol-6 is an intermediate in biosynthesis of ubiquinone-6 in Saccharomyces cerevisiae (methylated by the yeast enzyme COQ3 to ubiquinol-6). The human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast | Homo sapiens | S-adenosyl-L-homocysteine + ubiquinol-6 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 40998, calculated from sequence | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
COQ3 | - |
Homo sapiens |
Coq3 O-methyltransferase | - |
Homo sapiens |